Medicago has started recruiting participants for the Phase 3 trial of its COVID-19 vaccine candidate. (Medicago)

Medicago has started recruiting participants for the Phase 3 trial of its COVID-19 vaccine candidate. (Medicago)

Canadian company starts Phase 3 of plant-derived COVID-19 vaccine clinical trials

Feds have agreement to buy up to 76 million doses of the vaccine if it is approved

A Quebec-based biopharmaceutical company is beginning to recruit participants for its Phase 3 trial of a plant-derived COVID-19 vaccine.

In a Tuesday (March 16) news release, Medicago said that it had received approval from Canadian and U.S. regulators to begin enrolling adults into the Phase 3 portion of its trials based on positive interim Phase 2 results. That portion of the trial is almost complete, with results expected to be available publicly in April.

In parallel with the Phase 3 trial, Medicago said it has also started a feasibility study of a vaccine candidate to address emerging variants of concern.

The Canadian company is also partnering with GlaxoSmithKline, which is testing its vaccine adjuvant technology. According to the U.K.-based GlaxoSmithKline, the use of an adjuvant may reduce the amount of vaccine protein required per dose.

“We are pleased to take the significant step of initiating the Phase 3 clinical trial at sites around the world,” said Takashi Nagao, CEO and president of Medicago. “This brings us one step closer to delivering an important new COVID-19 vaccine and contributing to the global fight against the pandemic along with our partner GSK.”

Phase 3 of Medicago’s vaccine trials will enrol up to 30,000 healthy adults between the ages of 18 and 65, followed by adults over the age of 65 and adults with comorbidities. The trial will take place across 10 countries, starting with Canada and the U.S., and seeks to enrol men and women from racially diverse populations.

Ottawa has signed a deal with Medicago to secure the rights to buy 76 million doses of its vaccine. The federal government has also pledged $173 million for the company’s vaccine research and development and for the construction of its Quebec City manufacturing facility.

According to federal government data, just over five per cent of Canadians have received their first dose of a COVID-19 vaccine as of March 6.

READ MORE: Canadian company reports promising early Phase 1 test results of possible COVID-19 vaccine

READ MORE: Public Health Agency of Canada budgets $5B for COVID-19 vaccines, treatments


@katslepian

katya.slepian@bpdigital.ca

Like us on Facebook and follow us on Twitter.

Want to support local journalism during the pandemic? Make a donation here.

Coronavirusvaccines

Get local stories you won't find anywhere else right to your inbox.
Sign up here

Just Posted

The volume of visitors to White Rock’s Marine Drive over the weekend has led council to consider special measures this week. (Aaron Hinks photo)
White Rock council rejects resident-only parking for waterfront

Other health and safety measures to be considered in a special meeting Wednesday

South Surrey’s Paul Cottrell, who works with the DFO, tows a grey whale out of Semiahmoo Bay Sunday. (Contributed photo)
Dead whale floating near White Rock towed to shore for necropsy

Animal has been dead since at least April 15

Dr. Bonnie Henry gives her daily media briefing regarding Covid-19 for the province of British Columbia in Victoria, B.C, Monday, December 7, 2020. THE CANADIAN PRESS/Jonathan Hayward
BREAKING: Toddler marks youngest British Columbian to die related to COVID-19

Child one of eight people to die from virus this weekend

Vehicles line up for the Greater Vancouver Drive-Thru Food Truck Festival at the Chilliwack Coliseum parking lot on March 27. The touring event comes to Cloverdale this weekend, April 24-25 (Photo: Jenna Hauck/Chilliwack Progress)
Here are the food trucks coming to Cloverdale for a drive-thru festival this weekend

Nine trucks will be parked Saturday, nine Sunday during event at fairgrounds

Pharmacist Barbara Violo arranges all the empty vials of the Oxford-AstraZeneca COVID-19 vaccines that she has provided to customers at the Junction Chemist which is a independent pharmacy during the COVID-19 pandemic in Toronto, on Monday, April 19, 2021. THE CANADIAN PRESS/Nathan Denette
Parts of Surrey, North Delta to get AstraZeneca vaccines for people ages 40+

A total of seven communities in Surrey and Delta will be targeted

Public health restrictions on non-essential travel and vacation bookings are being increased in B.C. (B.C. government)
Out-of-region B.C. vacation bookings, RV ferry reservations to be refused, Horgan says

B.C. extends COVID-19 indoor dining, group fitness ban until May 25

Families of two of three workers killed in a train derailment near Field, B.C., in 2019 have filed lawsuits accusing Canadian Pacific of gross negligence. The derailment sent 99 grain cars and two locomotives off the tracks. THE CANADIAN PRESS/Jeff McIntosh
Families of workers killed in Field train derailment allege negligence in lawsuit

Lawsuits allege the workers weren’t provided a safe work environment

(New Westminster Police)
4 youth arrested after 30-person brawl in New Westminster leaves 1 seriously injured

Police are looking for witnesses who saw the incident take place

Sunday’s storm rocked one of the ferries crossing Kootenay Lake. Photo: Dirk Jonker
VIDEO: Storm makes for wild ferry ride across Kootenay Lake

The video was captured by ferry employee Dirk Jonker

Chakalaka Bar & Grill remains open in defiance of orders from Island Health to close. (Cole Schisler photo)
B.C. health authority seeks injunction against restaurant defying COVID-19 orders

Chakalaka Bar and Grill plans to continue serving customers without public health compliance

The Abbotsford Centre has the ability to host AHL level games if the Vancouver Canucks or any other NHL team chose to move its affiliate to the arena. (File photo)
Abbotsford Centre ready for AHL if right opportunity presents itself

Building recently upgraded glass and boards, schedule would allow for AHL tenant

A defeat Sunday in Kamloops tied up the Giants and Blazers for the most wins this season. Each team has notched seven victories in the B.C. division play unfolding this season on ice in Kamloops and Kelowna. (Allen Douglas/Special to Black Press Media)
VIDEO: Giants record fifth shutout of the season

Vancouver G-Men take down Kamloops Blazers on home ice Sunday, 4-0

Carver Ken Sheen had almost finished work on a large cowboy carving commissioned by the City of Williams Lake to replace the original overlooking the Stampede Grounds when fire broke out Friday, April 18 at his property between Williams Lake and Quesnel. (Pine River Carving Facebook photos)
Cow boss statue destined for Williams Lake Stampede Grounds goes up in flames

Carver Ken Sheen lost the statue, all his tools and his shop in the blaze

Most Read